* * * W A R N I N G! * * *
Say NO to ACE!
Acepromazine Warning
by Dr. Wendy Wallner, D.V.M.
What is Acepromazine?
There is one drug commonly used in anesthetic protocols that should not be used in the Boxer.
The drug is Acepromazine, a tranquilizer, which is often used as a preanesthetic agent. In the
Boxer, it tends to cause a problem called first degree heart block, a potentially serious arrhythmia
of the heart. It also causes a profound hypotension (severe lowering of the blood pressure) in
many Boxers that receive the drug.
Use in Boxers:
Recently, on the Veterinary Information Network, a computer network for practicing veterinarians,
an announcement was placed in the cardiology section entitled "Acepromazine and Boxers." This
described several adverse reactions to the drug in a very short time span at a veterinary teaching
hospital. All the adverse reactions were in Boxers. The reactions included collapse, respiratory arrest,
and profound bradycardia (slow heart rate, less than 60 beats per minute). The announcement
suggested that Acepromazine should not be used in dogs of the Boxer breed because of a breed
related sensitivity to the drug.
Warning:
This drug is the most commonly prescribed tranquilizer in veterinary medicine. It is also used orally
and is prescribed for owners who want to tranquilize their dogs for air or car travel. I would strongly
recommend that Boxer owners avoid the use of this drug, especially when the dog will be unattended
and/or unable to receive emergency medical care if it is needed.
© Dr. Wendy Wallner, D.V.M. July, 1997 (permission to use granted to Greater Ohio Boxer Rescue, Inc. by the author).
Please do not copy from this web page, instead contact the author
for permission to use.
The following is not part of Dr Wallner’s article. It is offered to help you provide informed
medical care of your Boxer.
If your vet is not yet aware of the potential risk of this drug on your Boxer (or other breeds referenced below)
ask them to please look in their "Handbook of Veterinary Drugs". In the 1993 edition, and others since, they
will find the below quoted statements in the “ACEPROMAZINE” section. (Note: the following may have been
updated since the below was quoted from the handbook.)
"Prolonged effects of the drug may be seen in older animals. Giant breeds, as well as greyhounds, appear
quite sensitive to the clinical effects of the drug, yet terrier breeds appear more resistant. Boxer dogs, on
the other hand, are predisposed to hypotensive and bradycardia effects of the drug."
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